An intelligent leakage current detection and interruption device for a power cord, including a switch module for controlling electrical connection of two power lines between input and output ends; a leakage current detection module, including two leakage current detection lines and a signal feedback line, one end of the parallelly coupled two leakage current detection lines being coupled via the signal feedback line to a point between the two power lines, for respectively detecting a leakage current on the two power lines; a detection monitoring module, coupled to the leakage current detection module, for detecting open circuit conditions in the two leakage current detection lines; and a drive module, coupled to the switch module, the leakage current detection module and the detection monitoring module, for driving the switch module to disconnect power to the output end in response to any detected leakage current or open circuit condition.