- 专利标题： Systems and methods for opening of a tissue barrier in primates
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申请号： US16575044申请日： 2019-09-18
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公开(公告)号： US11273329B2公开(公告)日： 2022-03-15
- 发明人: Elisa E. Konofagou , Fabrice Marquet , Yao-Sheng Tung
- 申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- 申请人地址： US NY New York
- 专利权人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- 当前专利权人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- 当前专利权人地址： US NY New York
- 代理机构： Baker Botts L.L.P.
- 主分类号： A61N7/00
- IPC分类号： A61N7/00 ; A61B17/225 ; A61B8/08 ; A61B17/00 ; A61B17/22 ; A61B90/10 ; A61B90/00
摘要：
Systems and methods for cavitation-guided opening of a targeted region of tissue within a primate skull are provided. In one example, a method includes delivering one or more microbubbles to proximate the targeted region, applying an ultrasound beam, using a transducer, through the skull of the primate to the targeted region to open the tissue, transcranially acquiring acoustic emissions produced from an interaction between the one or more microbubbles and the tissue, and determining a cavitation spectrum from the acquired acoustic emissions.
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