An electroluminescent display panel and manufacturing method thereof, and a display device are provided. The electroluminescent display panel includes a base substrate, pixel structures disposed on the base substrate; and an encapsulating layer disposed on the pixel structures. The pixel structures are arranged in an array, the pixel structure including a plurality of sub-pixels arranged in an array, the pixel structure array has a first direction and a second direction intersected with each other, the edge of the sub-pixel including a first portion gradually away from a straight line where the first direction lies, and an extending direction of the first portion does not coincide with the second direction.