Methods and apparatuses for selecting beam for preconfigured uplink resources in a wireless communication system are disclosed herein. In one method, a user equipment (UE) receives, from a network node, a signaling to configure at least one Preconfigured Uplink Resource (PUR) associated with one or more beams from multiple beams. The UE selects a first beam from the multiple beams and performs a transmission of data in RRC_INACTIVE state using the at least one PUR via the first beam if the first beam fulfills at least one condition, wherein the at least one condition comprises that the first beam is associated with the at least one PUR and Reference Symbol Received Power (RSRP) of the first beam is better than a first threshold. The UE initiates a Random Access (RA) procedure and performs the transmission during the RA procedure if no beam of the multiple beams fulfills the at least one condition.