Systems and methods for implementing a system architecture to support a trusted execution environment (TEE) with computational acceleration are provided. The method includes establishing a first trusted channel between a user application stored on an enclave and a graphics processing unit (GPU) driver loaded on a hypervisor. Establishing the first trusted channel includes leveraging page permissions in an extended page table (EPT) to isolate the first trusted channel between the enclave and the GPU driver in a physical memory of an operating system (OS). The method further includes establishing a second trusted channel between the GPU driver and a GPU device. The method also includes launching a unified TEE that includes the enclave and the hypervisor with execution of application code of the user application.