The present disclosure relates to a pixel arrangement structure, a display panel and a display device. The pixel arrangement structure includes: a first pixel area including a plurality of first-category pixel groups, each of which is arranged according to a first arrangement manner; and a second pixel area including a plurality of second-category pixel groups, each of which is arranged according to a second arrangement manner; wherein the first pixel area is adjacent to the second pixel area, and the first pixel area has a pixel density lower than a pixel density of the second pixel area.