A system, method and computer-readable medium for data uploading based on points of presence (POPs) are provided. In response to a client's request for data uploading, the system provides routing information for POPs that may facilitate data communications between the client and a data storage service provider. The client may fragment the upload data and transmit the data fragments via data connections to POPs, which in turn may relay the received fragments to the data storage service provider. Upon receipt of necessary data fragments, the data storage service provider may merge the data fragments to reconstruct a copy of the upload data for storage.