- 专利标题: Compounds for use in the elimination of pluripotent stem cells
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申请号: US16761172申请日: 2018-11-06
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公开(公告)号: US11299453B2公开(公告)日: 2022-04-12
- 发明人: Tomo Saric , Albrecht Berkessel , Karsten Burkert , Jürgen Hescheler
- 申请人: Universität zu Köln
- 申请人地址: DE Cologne
- 专利权人: Universität zu Köln
- 当前专利权人: Universität zu Köln
- 当前专利权人地址: DE Cologne
- 代理机构: Davidson, Davidson & Kappel, LLC
- 优先权: EP17200161 20171106
- 国际申请: PCT/EP2018/080325 WO 20181106
- 国际公布: WO2019/086707 WO 20190509
- 主分类号: C07C215/64
- IPC分类号: C07C215/64 ; C07D209/08 ; C07D209/14 ; C07D333/20 ; C12N5/077
摘要:
The present invention relates to a method of reducing the number or percentage of pluripotent stem cells or of enriching differentiating or differentiated cells in a cell population comprising pluripotent stem cells and differentiating cells or differentiated cells derived from the pluripotent stem cells, the method comprising the step of contacting the cell population with a compound according to the general formula (1).
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