- 专利标题: Polymorphic and amorphous forms of (R)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dienyl)butanamide
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申请号: US16919044申请日: 2020-07-01
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公开(公告)号: US11304914B2公开(公告)日: 2022-04-19
- 发明人: Paul Mollard , Peter Giannousis , Shazad Suchit , Mahmoud Mirmehrabi
- 申请人: PTC Therapeutics, Inc.
- 申请人地址: US NJ South Plainfield
- 专利权人: PTC Therapeutics, Inc.
- 当前专利权人: PTC Therapeutics, Inc.
- 当前专利权人地址: US NJ South Plainfield
- 代理机构: Squire Patton Boggs (US) LLP
- 主分类号: C07C235/78
- IPC分类号: C07C235/78 ; C07C215/28 ; C07C215/30 ; C07C231/12 ; C07C215/08 ; A61K31/122 ; C07B57/00 ; A61K31/164
摘要:
Disclosed herein are polymorphic and amorphous forms of anhydrate, hydrate, and solvates of (R)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dienyl)butanamide and methods of using such compositions for treating or suppressing oxidative stress disorders, including mitochondrial disorders, impaired energy processing disorders, neurodegenerative diseases and diseases of aging. Further disclosed are methods of making such polymorphic and amorphous forms.
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