- 专利标题： Benzofuran, benzothiophene, and indole analogs that inhibit the formation of tau oligomers and their method of use
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申请号： US16471424申请日： 2017-12-18
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公开(公告)号： US11306075B2公开(公告)日： 2022-04-19
- 发明人: Eliot J. Davidowitz , James G. Moe , Allen B. Reitz , Haiyan Bian , Charles Gluchowski , James Hendrix , Albert S. Yehaskel , Mark E. McDonnell , H. Marie Loughran
- 申请人： OLIGOMERIX INC.
- 申请人地址： US NY Bronx
- 专利权人： OLIGOMERIX INC.
- 当前专利权人： OLIGOMERIX INC.
- 当前专利权人地址： US NY Bronx
- 代理机构： Sorell, Lenna & Schmidt LLP
- 代理商 William D. Schmidt, Esq.
- 国际申请： PCT/US2017/067032 WO 20171218
- 国际公布： WO2018/118782 WO 20180628
- 主分类号： C07D409/14
- IPC分类号： C07D409/14 ; C07D307/80 ; C07D405/14
摘要：
Novel benzofurans, benzothiophenes and indoles useful as inhibitors of tau oligomer formation, useful for the treatment of neurodegenerative diseases and related conditions are disclosed. The invention also relates to the pharmaceutically acceptable salts of said compounds, processes for the preparation of said compounds, intermediates used in the preparation of said compounds, and pharmaceutical compositions containing said compounds. The invention further relates to methods of use of said compounds, salts of said compounds, and said compositions in treating neurodegenerative diseases and related conditions.
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