Invention Grant
![Substituted pyrrolo[1,2-a]pyrazines and pyrrolo[1,2-a][1,4]diazepines as TREX1 inhibitors](/docs/US/2022-04-19/US11306098B2/abs.jpg.600x600.jpg)
- Patent Title: Substituted pyrrolo[1,2-a]pyrazines and pyrrolo[1,2-a][1,4]diazepines as TREX1 inhibitors
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Application No.: US16829655Application Date: 2020-03-25
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Publication No.: US11306098B2Publication Date: 2022-04-19
- Inventor: Jeffrey J. Letourneau , Kiruthika Selvarangan Elamparuthi , Chia-Yu Huang , Venugopalareddy Bommireddy Venkata
- Applicant: VENENUM BIODESIGN, LLC
- Applicant Address: US NJ Hamilton
- Assignee: VENENUM BIODESIGN, LLC
- Current Assignee: VENENUM BIODESIGN, LLC
- Current Assignee Address: US NJ Hamilton
- Agency: Heslin Rothenberg Farley & Mesiti, P.C.
- Main IPC: A61K31/4985
- IPC: A61K31/4985 ; A61K31/551 ; C07D487/04 ; A61P35/00 ; A61K45/06
![Substituted pyrrolo[1,2-a]pyrazines and pyrrolo[1,2-a][1,4]diazepines as TREX1 inhibitors](/abs-image/US/2022/04/19/US11306098B2/abs.jpg.150x150.jpg)
Abstract:
The present invention provides compounds of Formula I wherein X, R1, R2, R3 and R4 are as defined herein, or a stereoisomer, tautomer, pharmaceutically acceptable salt, prodrug ester or solvate form thereof, wherein all of the variables are as defined herein. These compounds are effective at modulating the TREX1 protein and thus can be used as medicaments for treating or preventing disorders affected by the inhibition of TREX1.
Public/Granted literature
- US20200317677A1 NOVEL CYCLIC TREX1 INHIBITORS Public/Granted day:2020-10-08
Information query
IPC分类:
