Invention Grant
- Patent Title: Method of identifying a P-selectin glycoprotein ligand-1 (PSGL-1) antagonist
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Application No.: US16476814Application Date: 2018-01-10
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Publication No.: US11306150B2Publication Date: 2022-04-19
- Inventor: Robert J. Johnston , Andrew Rankin , Arathi Krishnakumar , Paul O. Sheppard , Arvind Rajpal
- Applicant: Bristol-Myers Squibb Company , Five Prime Therapeutics, Inc.
- Applicant Address: US NJ Princeton; US CA South San Francisco
- Assignee: Bristol-Myers Squibb Company,Five Prime Therapeutics, Inc.
- Current Assignee: Bristol-Myers Squibb Company,Five Prime Therapeutics, Inc.
- Current Assignee Address: US NJ Princeton; US CA South San Francisco
- Agency: McNeill Baur PLLC
- International Application: PCT/US2018/013171 WO 20180110
- International Announcement: WO2018/132476 WO 20180719
- Main IPC: C07K16/28
- IPC: C07K16/28 ; A61K45/06
Abstract:
Methods of identifying and using PSGL-1 antagonists are provided. Such methods include, but are not limited to, methods of treating cancer. PSGL-1 antagonists include, but are not limited to, antibodies that bind PSGL-1 and antibodies that bind VISTA, wherein the antibodies inhibit PSGL-1 binding to VISTA, e.g., at acidic pH (e.g., pH 6.0), as well as PSGL-1 and VISTA extracellular domain polypeptides.
Public/Granted literature
- US20190330364A1 PSGL-1 Antagonists and Uses Thereof Public/Granted day:2019-10-31
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