Systems and methods for an adaptive power drive in an illumination system are disclosed herein. An example method includes (1) analyzing, by one or more processors data in a memory to determine a configuration of one or more LEDs; (2) obtaining, by one or more processors, illumination control instructions for operating the one or more LEDs during one or more illumination cycles; (3) controlling, by one or more processors, one or more switches of an illumination unit in accordance with illumination control instructions; (4) determining, by one or more processors, a current requirement for operating the one or more LEDs in accordance with the illumination control instructions; and (5) setting, by one or more processors, a current control set point of an LED driver to the current requirement.