It is disclosed an anti-tampering assembly for the transportation and storage of a package, the anti-tampering assembly being configured to be associated with the package. the anti-tampering assembly comprises: a tampering detection unit comprising a RFID passive tag and a tampering track of a conductive material configured to be connected to said RFID tag upon dispatching the package so as to inhibit the operation of the RFID tag, wherein the tampering track is configured to be interrupted in case of tampering of the package; an actuating unit configured to detect the interruption of the tampering track in case of tampering of the package and, upon detection, actuate an alarm unit; and the alarm unit comprising a radio module configured to, upon actuation, transmit an alarm message over a long range wireless communication network.