- 专利标题: Modulating apolipoprotein (a) expression
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申请号: US16729980申请日: 2019-12-30
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公开(公告)号: US11319536B2公开(公告)日: 2022-05-03
- 发明人: Nicholas J. Viney , Richard S. Geary , Yanfeng Wang , Zhengrong Yu
- 申请人: Ionis Pharmaceuticals, Inc.
- 申请人地址: US CA Carlsbad
- 专利权人: Ionis Pharmaceuticals, Inc.
- 当前专利权人: Ionis Pharmaceuticals, Inc.
- 当前专利权人地址: US CA Carlsbad
- 代理商 Timothy P. O'Dea
- 主分类号: C12N15/113
- IPC分类号: C12N15/113 ; A61K9/00 ; C07K14/775 ; A61K31/7125 ; A61J1/05 ; A61K9/08
摘要:
Provided herein are oligomeric compounds with conjugate groups targeting apoplipoprotein (a). In certain embodiments, the apo(a) targeting oligomeric compounds are conjugated to N-Acetylgalactosamine. Also disclosed herein are conjugated oligomeric compounds targeting apo(a) for use in decreasing apo(a) to treat, prevent, or ameliorate diseases, disorders or conditions related to apo(a) and/or Lp(a). Certain diseases, disorders or conditions related to apo(a) and/or Lp(a) include inflammatory, cardiovascular and/or metabolic diseases, disorders or conditions. The conjugated oligomeric compounds disclosed herein can be used to treat such diseases, disorders or conditions in an individual in need thereof.