- 专利标题: Process for preparing immunoglobulin compositions
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申请号: US16320900申请日: 2017-07-26
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公开(公告)号: US11325964B2公开(公告)日: 2022-05-10
- 发明人: Oliver Maneg , Achim Hannappel , Alexander Moehlenkamp-Roettger , Wolfgang Moeller , Dieter Rudnick
- 申请人: Biotest AG
- 申请人地址: DE Dreieich
- 专利权人: Biotest AG
- 当前专利权人: Biotest AG
- 当前专利权人地址: DE Dreieich
- 代理机构: Lewis Kohn Walker LLP
- 代理商 David M. Kohn
- 优先权: EP16181493 20160727
- 国际申请: PCT/EP2017/068914 WO 20170726
- 国际公布: WO2018/019898 WO 20180201
- 主分类号: C07K16/06
- IPC分类号: C07K16/06 ; C07K1/30 ; C07K1/22 ; G01N33/68
摘要:
A process for the preparation of pharmaceutically acceptable immunoglobulin compositions from plasma-derived immunoglobulin fractions which allows the parallel preparation of immunoglobulin compositions enriched in IgG, IgM and IgA. In this process, immunoglobulin contained in Cohn fraction I/II/III or Kistler Nitschmann fraction A+I is resolubilized at conductivities of at least 1 mS/cm, and following removal of contaminating protein the resolubilized immunoglobulin is subjected to anion exchange chromatography to obtain IgG- and IgM/IgA-enriched immunoglobulin compositions. The IgG-enriched immunoglobulin composition is further subjected to treatment with a cation exchange material to obtain an immunoglobulin composition having a reduced properdin content.
公开/授权文献
- US20190161533A1 Process for Preparing Immunoglobulin Compositions 公开/授权日:2019-05-30