Invention Grant
- Patent Title: 3-(1H-pyrazol-4-yl)pyridine allosteric modulators of the M4 muscarinic acetylcholine receptor
-
Application No.: US16621953Application Date: 2018-06-22
-
Publication No.: US11339156B2Publication Date: 2022-05-24
- Inventor: John J. Acton, III , Jianming Bao , Qiaolin Deng , Melissa Egbertson , Ronald Ferguson, II , Xiaolei Gao , Scott Timothy Harrison , Timothy J. Henderson , Sandra L. Knowles , Chunsing Li , Michael Man-Chu Lo , Robert D. Mazzola, Jr. , Meng Na , Michael T. Rudd , Oleg B. Selyutin , David M. Tellers , Ling Tong , Fengqi Zhang , Takao Suzuki
- Applicant: Merck Sharp & Dohme Corp. , MSD R&D (China) Co., Ltd.
- Applicant Address: US NJ Rahway; CN Shanghai
- Assignee: Merck Sharp & Dohme Corp.,MSD R&D (China) Co., Ltd.
- Current Assignee: Merck Sharp & Dohme Corp.,MSD R&D (China) Co., Ltd.
- Current Assignee Address: US NJ Rahway; CN Shanghai
- Agent Eric A. Meade; John C. Todaro
- Priority: WOPCT/CN2017/090385 20170627
- International Application: PCT/US2018/038891 WO 20180622
- International Announcement: WO2019/005588 WO 20190103
- Main IPC: C07D471/04
- IPC: C07D471/04 ; C07D401/14 ; C07D405/14 ; C07D413/14 ; C07D487/04 ; C07D417/14
Abstract:
The present invention is directed to pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.
Public/Granted literature
- US20210380580A1 3-(1H-PYRAZOL-4-YL)PYRIDINE ALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR Public/Granted day:2021-12-09
Information query
