Systems and methods for musical performance are provided. In some embodiments, a system for musical performance includes a processing device to: receive performance information related to a first performance of a piece of music on a first musical instrument; generate at least one control signal based on the performance information; and produce a second performance based on the control signal, wherein to produce the second performance, the processing device is further to: control at least one tone generating device of a second musical instrument to perform the music using the control signal.