An apparatus for applying negative pressure to a tissue site proximate a patient's foot may include a tissue interface, a sole, a toe box, a cover, and an interface. The tissue interface may be configured to be circumferentially disposed around the tissue site. The sole may be configured to support the tissue interface. The toe box may be coupled to the sole. The cover may be configured to be coupled to the leg and to the sole to cover the tissue interface. The cover and the sole may form a chamber containing the tissue interface and may seal the tissue interface within the chamber. The interface may be configured to fluidly couple the tissue interface to a source of negative pressure, which can be delivered to the tissue interface for distribution to the tissue site.