A system includes a neural network implemented by one or more computers, in which the neural network includes an image depth prediction neural network and a camera motion estimation neural network. The neural network is configured to receive a sequence of images. The neural network is configured to process each image in the sequence of images using the image depth prediction neural network to generate, for each image, a respective depth output that characterizes a depth of the image, and to process a subset of images in the sequence of images using the camera motion estimation neural network to generate a camera motion output that characterizes the motion of a camera between the images in the subset. The image depth prediction neural network and the camera motion estimation neural network have been jointly trained using an unsupervised learning technique.