Systems and methods are provided for dynamically protecting transportable articles in vehicles. A system for dynamically protecting a transportable article in a vehicle may include one or more processors and non-volatile memory storing instructions. The instructions, when executed by the one or more processors, cause the system to access sensed data representative of at least one of a characteristic or a trait of a transportable article in a vehicle, determine based on the data the at least one of the characteristic or the trait of the transportable article, select one or more article protection components based on the determined at least one of the characteristic or the trait of the transportable article, and deploy the selected one or more article protection components to protect the transportable article.