A display device and a method of driving the same are provided. The method of driving the display includes a display area to display an image. The method includes performing a first pixel shift driving by shifting an image by a first range in the display area without loss of image information due to enlargement or reduction of the image, checking whether a change of a block grayscale value is greater than or equal to a threshold in an interest area in the display area, and performing second pixel shift driving by shifting an image having the loss of image information.