A light-emitting substrate and a method of driving the same, a light-emitting module, and a display apparatus are provided. The light-emitting substrate has a plurality of light-emitting areas. The light-emitting substrate includes: a base, a plurality of light-emitting components, a plurality of first power supply voltage signal lines, and a plurality of first control circuits. The plurality of light-emitting components are disposed on the base. The plurality of first power supply voltage signal lines are disposed on the base and arranged at intervals. The plurality of first control circuits are disposed on the base. One light-emitting component is located in one light-emitting area. Each of the first control circuits is coupled to a first electrode of one light-emitting component, and each of first power supply voltage signal lines is coupled to at least two first control circuits.