A trajectory guiding apparatus and one or more methods associated therewith for facilitating precision-guided alignment and implantation of a DBS therapy device in a patient. Orthogonally disposed first and second arcuate racks are independently actuatable by respective pinion drives, wherein the first arcuate rack is coupled to a base support and the second arcuate rack is operative to support a slider assembly arranged to accommodate an instrumentation column (IC) containing the therapy device. The first pinion drive is actuatable to cause a first curvilinear motion of the second arcuate rack including the slider assembly, the first curvilinear motion defined along a first arcuate path on a first perpendicular plane. The second pinion drive is actuatable to cause a second curvilinear motion associated with the slider assembly including the IC, the second curvilinear motion defined along a second arcuate path congruent with the second arcuate rack's curvature and disposed on a second perpendicular plane orthogonal to the first perpendicular plane.