- 专利标题： Compositions and methods of enhancing immune responses to eimeria or limiting eimeria infection
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申请号： US17023795申请日： 2020-09-17
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公开(公告)号： US11364290B2公开(公告)日： 2022-06-21
- 发明人: John R. Barta , Luc Berghman , Srichaitanya Shivaramaiah , Olivia B. Faulkner , Lisa Bielke , Billy Hargis
- 申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS , THE TEXAS A&M UNIVERSITY SYSTEM
- 申请人地址： US AR Little Rock; US TX College Station
- 专利权人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS,THE TEXAS A&M UNIVERSITY SYSTEM
- 当前专利权人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS,THE TEXAS A&M UNIVERSITY SYSTEM
- 当前专利权人地址： US AR Little Rock; US TX College Station
- 代理机构： Quarles & Brady, LLP
- 主分类号： A61K39/002
- IPC分类号： A61K39/002 ; C07K14/445 ; A61K39/012 ; A61K39/015 ; A61K39/00
摘要：
Vaccine vectors and methods of using the vaccine vectors to enhance the immune response to an Apicomplexan parasite and reduce the morbidity or mortality associated with subsequent infection are provided herein. The vaccine vectors include a polynucleotide encoding a Rhomboid polypeptide and optionally include an immune-stimulatory polypeptide suitably expressed on the surface of the vaccine vector.