Invention Grant
- Patent Title: High concentration anti-C5 antibody formulations
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Application No.: US16633930Application Date: 2018-07-27
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Publication No.: US11365241B2Publication Date: 2022-06-21
- Inventor: Stephan Ortiz , Jillian Gentile , Leena Philominathan , Eric Routhier , Bruce Mason
- Applicant: Alexion Pharmaceuticals, Inc.
- Applicant Address: US MA Boston
- Assignee: Alexion Pharmaceuticals, Inc.
- Current Assignee: Alexion Pharmaceuticals, Inc.
- Current Assignee Address: US MA Boston
- Agency: Nelson Mullins Riley & Scarborough LLP
- Agent Jane E. Remillard, Esq.; Jill Gorny Sloper, Esq.
- International Application: PCT/US2018/044071 WO 20180727
- International Announcement: WO2019/023564 WO 20190131
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/18 ; A61K9/00 ; A61K9/08 ; A61K47/18 ; A61K47/26 ; A61K39/00

Abstract:
The present disclosure relates to stable aqueous solutions comprising a high concentration of an anti-C5 antibody (e.g., ravulizumab) and methods for preparing the solutions. The disclosure also provides methods for treating or preventing complement-associated disorders, such as paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS), using the solutions. Also featured were therapeutic kits containing one or more of the solutions and a means for administering the solutions to a patient in need such a treatment.
Public/Granted literature
- US20200369751A1 HIGH CONCENTRATION ANTI-C5 ANTIBODY FORMULATIONS Public/Granted day:2020-11-26
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