A display panel, a method of manufacturing the same, and a display device are provided. The display panel includes a first substrate, a plurality of binding pins, and at least one binding alignment block. The first substrate includes a non-display area. The binding pins are disposed on the first substrate. An end of each of the binding pins extends to an edge of a binding side of the first substrate and is disposed on the non-display area. The at least one binding alignment block is disposed on the non-display area. A side of the at least one binding alignment block is in a same plane as the binding side of the first substrate, and a thickness of the at least one binding alignment block is greater than a thickness of each of the binding pins.