Communication device with configurable antenna interface and method for configuring an antenna interface. One implementation of the communication device includes an RF transceiver, a threaded coaxial antenna connector, a first RF terminal, a second RF terminal, an RF signal conduit, and an interface circuit. The threaded coaxial antenna connector includes inner and outer terminals. The RF signal conduit includes a first structure that couples the first RF terminal to the inner terminal of the threaded coaxial antenna connector. The RF signal conduit further includes a second structure that couples the second RF terminal to the outer terminal of the threaded coaxial antenna connector. The interface circuit is configured to set an SMA antenna interface mode by coupling the RF transceiver to the first RF terminal. The interface circuit is also configured to set a ferrule antenna interface mode by coupling the RF transceiver to the second RF terminal.