A device and method for altitude-based interference mitigation in an aerial vehicle. The device includes a transceiver, an altimeter, and an electronic processor coupled to the transceiver and the altimeter. The electronic processor is configured to determine, via the altimeter, an altitude level of the aerial vehicle, compare the altitude level to an altitude threshold, and, in response to the altitude level exceeding the altitude threshold, control a radio frequency characteristic of the transceiver to mitigate signal interference based the altitude level.