A powered fastener driver includes a housing, a nosepiece having a fastener driver channel from which fasteners are discharged into a workpiece, a driver blade, a workpiece contact element, a canister magazine, and a pusher mechanism coupled to the nosepiece. The powered fastener driver also includes a dry-fire lockout mechanism having a lockout lever movable between a bypass position and a blocking position and a last fastener holding member configured to engage a first side of a fastener within the fastener driver channel. The lockout lever is configured to engage an opposite, second side of the fastener within the fastener driver channel. The last fastener holding member biases the fastener within the fastener driver channel toward an inner surface of the fastener driver channel to inhibit the fastener from falling out of the fastener driver channel.