Invention Grant
- Patent Title: DNA sequencing via direct electrical detection with free single nucleotide pairing with polymerase
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Application No.: US16935111Application Date: 2020-07-21
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Publication No.: US11377686B2Publication Date: 2022-07-05
- Inventor: Thomas Young Chang
- Applicant: Seagate Technology LLC
- Applicant Address: US CA Fremont
- Assignee: Seagate Technology LLC
- Current Assignee: Seagate Technology LLC
- Current Assignee Address: US CA Fremont
- Agency: Holzer Patel Drennan
- Main IPC: C12Q1/6869
- IPC: C12Q1/6869 ; G01N33/487

Abstract:
A DNA sequencing device having a first conductor electrically insulated from a second conductor, a voltage source and an amplifier electrically connected in series with the first conductor and the second conductor, a DNA polymerase attached to the first conductor and to the second conductor with matching biotinylated tag molecules, and an electric current monitor. A non-discriminating electrical signal is provided by the polymerase during pairing, which signal can be used as a marker to indicate that transcription is occurring between a single-type of free nucleotide and a base nucleotide of a template DNA strand.
Public/Granted literature
- US20210054447A1 DNA SEQUENCING VIA DIRECT ELECTRICAL DETECTION WITH FREE SINGLE NUCLEOTIDE PAIRING WITH POLYMERASE Public/Granted day:2021-02-25
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