At least some embodiments of the present disclosure are directed to systems and methods for controlling a cylinder deactivation (CDA) operation for an electrified powertrain, the electrified powertrain comprising an engine and an additional power source, the engine having a plurality of cylinders. The method includes the step of: operating the electrified powertrain in a CDA mode and deactivating one or more selected cylinders of the plurality of cylinders; receiving measurement data indicative of operating conditions of the electrified powertrain; analyzing the measurement data to determine whether a predetermined operating condition is met; and adjusting the CDA operation by adjusting the duration of the CDA operation or changing a number of deactivated cylinders.