The embodiments described herein include sensor mounting clamps configured to lock a sensor, such as a temperature sensor, in place relative to a structure, such as a pipe or tube, of a heating, ventilating, and/or air conditioning (HVAC) unit. More specifically, the sensor mounting clamps described herein include sensor mounting portions configured to receive a sensor, and to hold the sensor in place relative to a structure of an HVAC unit. In addition, the sensor mounting clamps described herein include locking mechanisms having interlocking pockets configured to lock the sensor mounting clamps in place around a structure of an HVAC unit. For example, the sensor mounting clamps described herein may include interlocking pockets having interior passages configured to receive a retention piece, such as a cotter pin, cylindrical pin, or screw, to lock the interlocking pockets in place relative to each other, or may include interlocking pockets configured to directly engage with each other. In addition, the sensor mounting clamps described herein may include a flange configured to constrain longitudinal motion of a sensor.