Buttons and other interactive functionality for touchscreen displays of e-book and other electronic media content can be automatically optimized for viewing on client devices, in particular those employing an electrophoretic display. A hardware display driver pushes e-ink material through various predetermined voltage waveforms to consistently accomplish interface effects such as color inversion for a button which is touched on the interface screen. Machine learning schema can assist in determining the appropriate waveforms for interactive elements in the content.