One or more devices, systems, methods and storage mediums for performing optical coherence tomography (OCT) while detecting one or more lumen edges and/or one or more artifacts are provided. Examples of applications include imaging, evaluating and diagnosing biological objects, such as, but not limited to, for Gastro-intestinal, cardio and/or ophthalmic applications, and being obtained via one or more optical instruments, such as, but not limited to, optical probes, catheters, capsules and needles (e.g., a biopsy needle). Preferably, the OCT devices, systems methods and storage mediums include or involve a method, such as, but not limited to, for removing the detected one or more artifacts from the image(s).