Invention Grant
- Patent Title: Maleate salt of benzothiophene compound, crystalline form thereof, and use thereof
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Application No.: US17127350Application Date: 2020-12-18
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Publication No.: US11384073B2Publication Date: 2022-07-12
- Inventor: Jingshan Shen , Yang He , Zhen Wang , Jianfeng Li , Yongjian Liu , Jin Suo , Guanghui Tian , Weiming Chen , Feipu Yang , Yu Wang , Xiangrui Jiang , Rongxia Zhang , Hualiang Jiang
- Applicant: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES , SUZHOU VIGONVITA LIFE SCIENCES CO., LTD. , TOPHARMAN SHANGHAI CO., LTD.
- Applicant Address: CN Shanghai; CN Jiangsu; CN Shanghai
- Assignee: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES,SUZHOU VIGONVITA LIFE SCIENCES CO., LTD.,TOPHARMAN SHANGHAI CO., LTD.
- Current Assignee: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES,SUZHOU VIGONVITA LIFE SCIENCES CO., LTD.,TOPHARMAN SHANGHAI CO., LTD.
- Current Assignee Address: CN Shanghai; CN Jiangsu; CN Shanghai
- Agency: Reinhart Boerner Van Deuren P.C.
- Priority: CN201810646314.7 20180621
- Main IPC: C07D409/12
- IPC: C07D409/12

Abstract:
The present disclosure relates to a maleate salt of a benzothiophene compound, a crystalline form thereof, and a use thereof. Specifically, the present disclosure relates to a compound represented by formula (I-A), a crystalline form A thereof, a preparation method of a pharmaceutical composition including the same, and a use of the pharmaceutical composition in the preparation of drugs for preventing or treating diseases of the central nervous system. The compound represented by formula (I-A) and the crystalline form A thereof in the present disclosure have excellent physical and chemical properties, high oral bioavailability, excellent drugability, and are well-suited for pharmaceutical preparation, application, and preservation.
Public/Granted literature
- US20210309648A1 MALEATE SALT OF BENZOTHIOPHENE COMPOUND, CRYSTALLINE FORM THEREOF, AND USE THEREOF Public/Granted day:2021-10-07
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