A method for predicting collision of a machining path includes: a step of reading an NC program; a step of translating a plurality of block information in the NC program; a step of, prior to perform interpolation upon each of the plurality of block information, calculating a safety distance of a next block information with respect to a block information to be interpolated; a step of searching a number of individual block information having an accumulated distance greater than or equal to the safety distance; and a step of performing an anti-collision detection upon each of the individual block information contributing the accumulated distance. In addition, a system for predicting collision of a machining path is also provided.