- 专利标题： Inhibitors of tryptophan dioxygenases (IDO1 and TDO) and their use in therapy
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申请号： US15755750申请日： 2016-08-25
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公开(公告)号： US11414428B2公开(公告)日： 2022-08-16
- 发明人: Brian Desmond Palmer , Lai-Ming Ching
- 申请人： Auckland UniServices Limited
- 申请人地址： NZ Auckland
- 专利权人： Auckland UniServices Limited
- 当前专利权人： Auckland UniServices Limited
- 当前专利权人地址： NZ Auckland
- 代理机构： McDonnell Boehnen Hulbert & Berghoff LLP
- 优先权： NZ711514 20150827
- 国际申请： PCT/NZ2016/050135 WO 20160825
- 国际公布： WO2017/034420 WO 20170302
- 主分类号： C07D498/04
- IPC分类号： C07D498/04 ; A61K31/437 ; A61P35/00 ; A61K45/06
摘要：
Pharmaceutical compositions comprising 3-aminoisoxazolopyridine compounds of the Formula I having IDO1 and/or TDO inhibitory activity are described, where W is CR1, N or N-oxide; X is CR2, N or N-oxide; Y is CR3, N or N-oxide; Z is CR4, N or N-oxide; and at least one of W, X, Y, and Z is N or N-oxide; and R9 and R10 are as defined. Also described are methods of using such compounds in the treatment of various conditions, such as cancer.
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