A pixel circuit and a driving method therefor, and a display substrate and a display device are disclosed. The pixel circuit includes a compensation circuit. The compensation circuit may output an initial power supply signal to a first node, and a driving circuit may drive a light-emitting element to emit light according to a potential of the first node and a second power supply signal provided by a second power supply end. And, each driving circuit which the display panel includes may start to work from the same bias situation and drive the corresponding light-emitting element to emit light.