Invention Grant
- Patent Title: Antibodies specific for FLT3 and their uses
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Application No.: US15993874Application Date: 2018-05-31
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Publication No.: US11421040B2Publication Date: 2022-08-23
- Inventor: Danielle Elizabeth Dettling , Yik Andy Yeung , Kristian Todd Poulsen , Veena Krishnamoorthy , Cesar Adolfo Sommer
- Applicant: PFIZER INC.
- Applicant Address: US NY New York
- Assignee: PFIZER INC.
- Current Assignee: PFIZER INC.
- Current Assignee Address: US NY New York
- Main IPC: C07K16/46
- IPC: C07K16/46 ; C07K16/28 ; A61P35/02 ; A61P35/00 ; A61K39/00
Abstract:
The present invention provides antibodies that specifically bind to FLT3 (Fms-Like Tyrosine Kinase 3). The invention further provides bispecific antibodies that bind to FLT3 and another antigen (e.g., CD3). The invention further relates to antibody encoding nucleic acids, and methods of obtaining such antibodies (monospecific and bispecific). The invention further relates to therapeutic methods for use of these antibodies for the treatment of FLT3-mediated pathologies, including cancer such as Acute Myeloid Leukemia (AML).
Public/Granted literature
- US20180346601A1 ANTIBODIES SPECIFIC FOR FLT3 AND THEIR USES Public/Granted day:2018-12-06
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