- 专利标题： Plasmid addiction system to drive desired gene expression
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申请号： US16036261申请日： 2018-07-16
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公开(公告)号： US11421239B2公开(公告)日： 2022-08-23
- 发明人: Matthew de la Pena Mattozzi , Daniel Kim , Sonya Clarkson
- 申请人： Conagen, Inc.
- 申请人地址： US MA Bedford
- 专利权人： Conagen, Inc.
- 当前专利权人： Conagen, Inc.
- 当前专利权人地址： US MA Bedford
- 代理机构： Wolf, Greenfield & Sacks, P.C.
- 代理商 W. John Keyes
- 主分类号： C12N1/21
- IPC分类号： C12N1/21 ; C12N15/70 ; C12P21/00 ; C12P21/02
摘要：
The present invention relates to a Plasmid Addiction System for the stabilization of expression plasmids encoding proteins of interest. The invention uses a succinate cycle optimization to ensure the expression of plasmid(s) of interest. By ensuring that plasmids of interest contain genes necessary in the succinate cycle, the system ensures that the passage of the plasmid to daughters and therefore improves the efficiency of production and expression of genes and/or products of interest.
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