A method for detecting change in a pair of sequential images. The method includes training a feature descriptor based on a generated training set of matching and non-matching image pairs. An imaging subsystem captures a pair of substantially sequential images of a field of view. The pair of captured images is aligned and then transformed into corresponding arrays of patches. A matching and non-matching probability is determined for each pair of adjacent patches based on the feature descriptor. Each pair of patches is classified as matching or non-matching based on a comparison of the matching and non-matching probability. A mask is generated identifying the pairs of patches that indicate change and then displayed overlaid on at least one of the sequential images to indicate change on a user interface.