The present disclosure is directed to an aerosol delivery device and a holder for use with a removable substrate cartridge. The holder may include a first body portion and a second body portion. The first body portion may define a longitudinal axis, a rotational axis, and an aerosol passage. The second body portion may include a cartridge receiving chamber and may be configured to slide along the longitudinal axis and rotate about the rotation axis relative to the first body portion to and from a use position, wherein at least a portion of the second body is received by the first body portion and the substrate cartridge is retained in the receiving chamber, and an open position, wherein the second body portion is rotated relative to and extended away from the first body portion such that the substrate cartridge can be inserted into or removed from the receiving chamber.