Invention Grant
- Patent Title: Substituted indole compounds useful as inhibitors of TLR7/8/9
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Application No.: US16635593Application Date: 2018-08-03
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Publication No.: US11447466B2Publication Date: 2022-09-20
- Inventor: Alaric J. Dyckman , Dharmpal S. Dodd , Tasir Shamsul Haque , Brian K. Whiteley , John L. Gilmore
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee Address: US NJ Princeton
- Agent Gary Greenblatt
- International Application: PCT/US2018/045082 WO 20180803
- International Announcement: WO2019/028302 WO 20190207
- Main IPC: A61K31/4545
- IPC: A61K31/4545 ; A61P29/00 ; A61P37/00 ; C07D401/14 ; C07D405/14 ; C07D409/14 ; C07D413/14

Abstract:
Disclosed are compounds of Formula (I) or a salt thereof, wherein: Y is Formula (II), or Formula (III); R1, R2, R2a, R2b, R2c, R3, R4, R5, m, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.
Public/Granted literature
- US20200239437A1 SUBSTITUTED INDOLE COMPOUNDS USEFUL AS INHIBITORS OF TLR7/8/9 Public/Granted day:2020-07-30
Information query
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