Invention Grant
- Patent Title: Spiroheptanyl hydantoins as rock inhibitors
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Application No.: US16629784Application Date: 2018-07-11
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Publication No.: US11447487B2Publication Date: 2022-09-20
- Inventor: Benjamin P. Vokits , Scott A. Shaw
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee Address: US NJ Princeton
- Agent Hong Liu
- International Application: PCT/US2018/041563 WO 20180711
- International Announcement: WO2019/014304 WO 20190117
- Main IPC: C07D401/12
- IPC: C07D401/12 ; C07D471/04 ; C07D401/14 ; C07D405/14 ; C07D487/04

Abstract:
The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.
Public/Granted literature
- US20210155618A1 SPIROHEPTANYL HYDANTOINS AS ROCK INHIBITORS Public/Granted day:2021-05-27
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