- 专利标题： Producing adipate, 6-aminocaproate, hexamethylenediamine or caprolactam in the presence of methanol using a microorganism having increased availability of reducing equivalents
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申请号： US16178432申请日： 2018-11-01
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公开(公告)号： US11447804B2公开(公告)日： 2022-09-20
- 发明人: Anthony P. Burgard , Robin E. Osterhout , Stephen J. Van Dien , Cara Ann Tracewell , Priti Pharkya , Stefan Andrae
- 申请人： Genomatica, Inc.
- 申请人地址： US CA San Diego
- 专利权人： Genomatica, Inc.
- 当前专利权人： Genomatica, Inc.
- 当前专利权人地址： US CA San Diego
- 代理机构： Greenberg Traurig
- 主分类号： C12P17/10
- IPC分类号： C12P17/10 ; C12P7/44 ; C12P7/24 ; C12P13/00 ; C12N9/04 ; C08G63/78 ; C08G73/02 ; C08G69/16 ; C08G69/08 ; A23L29/00 ; C12N15/52
摘要：
Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as adipate, 6-aminocaproate, hexamethylenediamine or caprolactam. Also provided herein are methods for using such an organism to produce adipate, 6-aminocaproate, hexamethylenediamine or caprolactam.