- Patent Title: Producing adipate, 6-aminocaproate, hexamethylenediamine or caprolactam in the presence of methanol using a microorganism having increased availability of reducing equivalents
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Application No.: US16178432Application Date: 2018-11-01
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Publication No.: US11447804B2Publication Date: 2022-09-20
- Inventor: Anthony P. Burgard , Robin E. Osterhout , Stephen J. Van Dien , Cara Ann Tracewell , Priti Pharkya , Stefan Andrae
- Applicant: Genomatica, Inc.
- Applicant Address: US CA San Diego
- Assignee: Genomatica, Inc.
- Current Assignee: Genomatica, Inc.
- Current Assignee Address: US CA San Diego
- Agency: Greenberg Traurig
- Main IPC: C12P17/10
- IPC: C12P17/10 ; C12P7/44 ; C12P7/24 ; C12P13/00 ; C12N9/04 ; C08G63/78 ; C08G73/02 ; C08G69/16 ; C08G69/08 ; A23L29/00 ; C12N15/52
Abstract:
Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as adipate, 6-aminocaproate, hexamethylenediamine or caprolactam. Also provided herein are methods for using such an organism to produce adipate, 6-aminocaproate, hexamethylenediamine or caprolactam.
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