A method for operating an industrial automation system may involve receiving, via a first module of a plurality of modules in a control system, an indication that an error between a measurement associated with a target variable that corresponds with at least a portion of the industrial automation system and a modeled value for the target variable. The method may then involve determining, via the first module, whether the error is within a first range of values and retraining a model used to generate the modeled value for the target variable based on a portion of a plurality of sets of data points acquired via a plurality of sensors disposed in the industrial automation system in response to the error being within the first range of values.