A method and apparatus for confirmation of multiple configured grants for sidelink in a wireless communication system is provided. A wireless device receives activation command or deactivation command on Physical Downlink Control Channel (PDCCH) for at least one of the multiple configured grants. A wireless device receives transmits, to the network, a confirmation Media Access Control (MAC) Control Element (CE). The confirmation MAC CE includes one or more fields in a bit group of which size is equal to number of the multiple configured grants. Each field in the bit group is set to (i) zero to indicate deactivation for each of the multiple configured grants or (ii) 1 to indicate activation for each of the multiple configured grants. Each field in the confirmation MAC CE except the bit group is ignored.