A parcel cart for transporting parcels comprises a substructure, with a frame mounted to and supported by the substructure. The frame defines an internal volume in which parcels are received and stored for transport. The frame also includes: a base; a first end wall; a second end wall; a first side wall; and a second side wall. To facilitate loading or unloading of the parcel cart, the frame can include at least one end wall configured to transition between an upright position and a lowered position. To facilitate autonomous transport of the parcel cart, the substructure and the frame can define a cavity for receiving a mobile robot. To avoid occlusion of the field of view of one or more cameras associated with the mobile robot, the frame can include at least one end wall that is in a non-perpendicular orientation relative to the base.